Omeprazole (Prilosec)

ATI-format individual drug card with NCLEX-focused assessment, safety, teaching, and source attribution.

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Omeprazole (Prilosec)

ATI class: Proton pump inhibitor / GI acid reducer

Action

  • Suppresses gastric acid secretion by inhibiting the proton pump in parietal cells.

Therapeutic use

  • GERD
  • Peptic ulcer disease
  • Erosive esophagitis
  • H. pylori regimens with antibiotics when ordered

Nursing assessment

  • Assess reflux, abdominal pain, dysphagia, GI bleeding cues, and response to therapy.
  • Monitor magnesium and B12 concerns with long-term therapy when ordered.
  • Watch for diarrhea that could suggest C. difficile risk.

Administration

  • PO capsule
  • PO tablet
  • Oral suspension

Side effects

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea

Adverse effects

  • C. difficile-associated diarrhea
  • Hypomagnesemia with long-term use
  • Fracture risk with long-term high-dose use
  • Acute interstitial nephritis

Interactions

  • Clopidogrel
  • Warfarin
  • Methotrexate
  • Drugs needing acidic gastric pH for absorption

Contraindications

  • Hypersensitivity

Precautions

  • Use caution with long-term therapy, osteoporosis risk, severe liver disease, and interacting medications.

Client teaching

  • Take before meals as directed and do not crush delayed-release products unless product directions allow.
  • Report severe diarrhea, black stools, vomiting blood, trouble swallowing, or unexplained weight loss.
  • Do not stop or extend long-term therapy without provider guidance.

Medication outcomes

  • Reduced reflux symptoms
  • Healing of erosive esophagitis or ulcer disease
  • Reduced gastric acid exposure

Antidote / rescue

  • No specific antidote is seeded; toxicity or severe reaction care is supportive and provider-directed.

NCLEX priority cues

  • Severe watery diarrhea after acid suppression can be a C. difficile cue.
  • Long-term PPI therapy makes magnesium, B12, bone, and infection risk testable.
  • Clopidogrel interaction is a medication-reconciliation cue.

Medication classes

GI acid reducers

Source attribution

Engage_MedTable_Omeprazole.pdf
ati-pdf
Google Drive source topic: Over-the-counter meds
google-drive
Sentinel pharmacology API reference
sentinel-api
Manual ATI-format NCLEX normalization
manual-seed

Related study cards

Shows the medication class, ATI cues, source references, and connected study cards for this drug.

12 study links
Med classmedication class
GI acid reducers

Reduces stomach acid so irritated tissue can heal and reflux symptoms decrease.

ATI cueSide Effect
Abdominal pain

ATI medication side effect concept.

ATI cueAdverse Effect
Acute interstitial nephritis

ATI medication adverse effect concept.

ATI cueNursing Assessment
Assess reflux, abdominal pain, dysphagia, GI bleeding cues, and response to therapy.

ATI medication nursing assessment concept.

ATI cueAdverse Effect
C. difficile-associated diarrhea

ATI medication adverse effect concept.

ATI cueInteraction
Clopidogrel

ATI medication interaction concept.

ATI cueNCLEX Priority Cue
Clopidogrel interaction is a medication-reconciliation cue.

ATI medication nclex priority cue concept.

ATI cueSide Effect
Diarrhea

ATI medication side effect concept.

ATI cueClient Teaching
Do not stop or extend long-term therapy without provider guidance.

ATI medication client teaching concept.

ATI cueInteraction
Drugs needing acidic gastric pH for absorption

ATI medication interaction concept.

ATI cueTherapeutic Use
Erosive esophagitis

ATI medication therapeutic use concept.

ATI cueAdverse Effect
Fracture risk with long-term high-dose use

ATI medication adverse effect concept.