Aprepitant (Emend, Aponvie, Cinvanti)

ATI-format individual drug card with NCLEX-focused assessment, safety, teaching, and source attribution.

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GI / Liver / PancreasIntegumentary / Burns / Woundsneeds review

Aprepitant (Emend, Aponvie, Cinvanti)

ATI class: Antiemetic / NK1 receptor antagonist

Action

  • Blocks substance P/neurokinin-1 receptors involved in the vomiting pathway.
  • Helps prevent delayed nausea and vomiting with emetogenic therapy.

Therapeutic use

  • Chemotherapy-induced nausea and vomiting
  • Postoperative nausea and vomiting

Nursing assessment

  • Assess nausea, vomiting, bowel sounds, and abdominal pain.
  • Monitor for rash, blistering, mucosal lesions, or other severe skin reaction cues.
  • Assess hypersensitivity or anaphylaxis symptoms with IV formulations.

Administration

  • PO
  • IV

Side effects

  • Dizziness
  • Fatigue
  • Weakness
  • Hiccups

Adverse effects

  • Stevens-Johnson syndrome
  • Hypersensitivity
  • Anaphylaxis

Interactions

  • Warfarin
  • Oral contraceptives
  • Phenytoin
  • Pimozide

Contraindications

  • Concurrent pimozide use because of serious dysrhythmia risk

Precautions

  • Use caution with severe liver disease.
  • Safety limits vary by age and formulation; verify the ordered product and current pediatric guidance.
  • Use additional nonhormonal contraception during and after therapy as instructed.

Client teaching

  • Use backup nonhormonal contraception because hormonal contraception can be less effective.
  • Report rash, skin peeling, mouth sores, swelling, wheezing, or faintness immediately.
  • Keep scheduled doses tied to the chemotherapy or procedure plan.

Medication outcomes

  • Decreased nausea and vomiting

Antidote / rescue

  • No specific antidote is seeded; stop/question therapy and treat severe allergy or skin reaction as urgent.

NCLEX priority cues

  • Rash with mucosal involvement is not a minor side effect.
  • Pimozide interaction is a hard stop because of dysrhythmia risk.
  • Oral contraceptive teaching is a classic safety point.

Medication classes

Antiemetics

Source attribution

Engage_MedTable_Aprepitant.pdf
ati-pdf
Google Drive ATI Engage antiemetic source folder
google-drive
Sentinel pharmacology API reference
sentinel-api

Related study cards

Shows the medication class, ATI cues, source references, and connected study cards for this drug.

12 study links
Med classmedication class
Antiemetics

Reduces nausea through different pathways, including serotonin, dopamine, histamine, muscarinic, cannabinoid, and NK1 receptor effects.

ATI cueAdverse Effect
Anaphylaxis

ATI medication adverse effect concept.

ATI cueClass
Antiemetic

ATI medication class concept.

ATI cueNursing Assessment
Assess hypersensitivity or anaphylaxis symptoms with IV formulations.

ATI medication nursing assessment concept.

ATI cueNursing Assessment
Assess nausea, vomiting, bowel sounds, and abdominal pain.

ATI medication nursing assessment concept.

ATI cueMechanism of Action
Blocks substance P/neurokinin-1 receptors involved in the vomiting pathway.

ATI medication mechanism of action concept.

ATI cueTherapeutic Use
Chemotherapy-induced nausea and vomiting

ATI medication therapeutic use concept.

ATI cueContraindication
Concurrent pimozide use because of serious dysrhythmia risk

ATI medication contraindication concept.

ATI cueMedication Outcome
Decreased nausea and vomiting

ATI medication medication outcome concept.

ATI cueSide Effect
Dizziness

ATI medication side effect concept.

ATI cueSide Effect
Fatigue

ATI medication side effect concept.

ATI cueMechanism of Action
Helps prevent delayed nausea and vomiting with emetogenic therapy.

ATI medication mechanism of action concept.